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While retatrutide offers numerous potential benefits, candidates must be in generally good health regarding contraindications
It can mess with your electrolyte balance, leading to things like fatigue, dizziness, and even muscle cramps
Laboratory and animal studies suggest GLP-1 receptor agonists may also inhibit nuclear factor-kappa B (NF-B) signaling, a key pathway in inflammatory gene expression, and reduce oxidative stress through enhanced antioxidant enzyme activity
The interaction with the NO system also partially explains proposed cardiovascular effects in rodent models
Zhang et al., 2024
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